Dnm1 forms spirals that are structurally tailored to fit mitochondria. Phospholipase D1: a key factor for the exocytotic machinery in neuroendocrine cells. Interdependent assembly of specific regulatory lipids and membrane fusion proteins into the vertex ring domain of docked vacuoles. A common lipid links Mfn-mediated mitochondrial fusion and SNARE-regulated exocytosis. Genetic basis of mitochondrial function and morphology in Saccharomyces cerevisiae. Role of essential genes in mitochondrial morphogenesis in Saccharomyces cerevisiae. Regulation of mitochondrial morphology through proteolytic cleavage of OPA1. Separate fusion of outer and inner mitochondrial membranes. Mitochondrial fusion in human cells is efficient, requires the inner membrane potential, and is mediated by mitofusins. OPA1 requires mitofusin 1 to promote mitochondrial fusion. Mitochondrial inner-membrane fusion and crista maintenance requires the dynamin-related GTPase Mgm1. Structural basis of mitochondrial tethering by mitofusin complexes. Disruption of fusion results in mitochondrial heterogeneity and dysfunction. Complementation between mouse Mfn1 and Mfn2 protects mitochondrial fusion defects caused by CMT2A disease mutations. This study described an in vitro fusion assay that identifies mitochondrial fusion intermediates.ĭetmer, S. Mitochondrial fusion intermediates revealed in vitro. Mitochondrial dynamics and division in budding yeast. Mitochondrial fusion in yeast requires the transmembrane GTPase Fzo1p. Differential protein distributions define two sub-compartments of the mitochondrial inner membrane in yeast. Dynamic subcompartmentalization of the mitochondrial inner membrane. The cristal membrane of mitochondria is the principal site of oxidative phosphorylation. A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis. Structure and dynamics of the mitochondrial inner membrane cristae. Nerve growth factor signaling regulates motility and docking of axonal mitochondria. Mitochondrial trafficking to synapses in cultured primary cortical neurons. The regulation of bidirectional mitochondrial transport is coordinated with axonal outgrowth. Kinesin-1 and dynein are the primary motors for fast transport of mitochondria in Drosophila motor axons. Axonal mitochondrial transport and potential are correlated. The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses. Role of microtubules and actin filaments in the movement of mitochondria in the axons and dendrites of cultured hippocampal neurons. Axonal transport of mitochondria along microtubules and F-actin in living vertebrate neurons. Live cell imaging of mitochondrial movement along actin cables in budding yeast. This study identified the first component of the mitochondrial fusion machinery, thereby providing an avenue to identify new components in further yeast genetic screens.įehrenbacher, K. Developmentally regulated mitochondrial fusion mediated by a conserved, novel, predicted GTPase. Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cells. Division versus fusion: Dnm1p and Fzo1p antagonistically regulate mitochondrial shape. Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development. The dynamin-related GTPase Dnm1 regulates mitochondrial fission in yeast. Mitochondrial transmission during mating in Saccharomyces cerevisiae is determined by mitochondrial fusion and fission and the intramitochondrial segregation of mitochondrial DNA. Mitochondrial morphology and dynamics in yeast and multicellular eukaryotes. Mitochondrial fusion and fission in mammals.
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